The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Last updated on Nov 11, 2020. Ondansetron (Zofran) is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy. Ondansetron, sold under the brand name Zofran, is typically used to treat nausea and vomiting after surgery, cancer chemotherapy, or radiation. [Ref], Common (1% to 10%): Injection site reactions[Ref], Rare (0.01% to 0.1%): Immediate hypersensitivity reactions (sometimes severe), anaphylaxis/anaphylactoid reactions, Frequency not reported: Poor oral intake[Ref], 1. Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. Many of the cases of blindness resolved from within a few minutes to approximately 28 hours. Transient visual disturbances, blurred vision, and transient blindness occurred predominantly during rapid IV administration. Shock 13. The National Institutes of Health lists the following as common side effects. Along with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Stevens-Johnson Syndrome 15. At the extreme end, the use of the drug caused fetal death including miscarriage and stillbirth. Common side effects associated with Zofran include headache, drowsiness, constipation and the chills. Many times, it is used for people receiving cancer treatments, such as radiation therapy or chemotherapy. Common side effects of Zofran include headache, feeling unwell (malaise), fatigue, drowsiness, constipation, dizziness, and diarrhea. Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. More common side effects. Ondansetron is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy.It is also used to prevent or treat nausea and vomiting after surgery. Ondansetron is a common medication that can be used to treat vomiting in dogs and cats. In fact, along with the risks of birth defects in their infants, other side effects that directly affect the mother include: Doctors also prescribe it to pregnant women who have extreme or debilitating morning sickness. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. [Ref], Common (1% to 10%): Anxiety/agitation, disturbance in behavior/conduct, sleep disturbance[Ref], Common (1% to 10%): Gynecological disorder, urinary retention, urinary tract infection/dysuria[Ref], Very rare (less than 0.01%): Toxic skin eruption, toxic epidermal necrolysis[Ref], Common (1% to 10%): Asymptomatic increases in AST/ALT, Postmarketing reports: Liver failure and death[Ref]. The safety of Zofran during pregnancy is an issue in Canada as well. Most side effects of Zofran are mild or moderate, but some may be severe or life-threatening. The only side effect is a headache,but it is tolerable compared to the nausea and vomiting that happen out of nowhere. It’s a drug that blocks the action of serotonin, a naturally occurring substance that can lead to nausea and vomiting. Note: This document contains side effect information about ondansetron. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Dizziness occurred during rapid IV administration. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. What Is Ondansetron? In clinical trials of patients taking Zofran to prevent nausea and vomiting associated with chemotherapy, nearly a quarter of patients taking 8 mg of the drug twice daily experienced a headache. If you struggle with nausea … Abnormal Heart Electrical Signals 2. Although not all of these side effects may occur, if they do occur they may need medical attention. "Product Information. Prolonged QT Interval On EKG 12. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to ondansetron: injectable solution, intravenous solution, oral disintegrating strip, oral solution, oral tablet, oral tablet disintegrating, The most frequently reported side effects are headache, constipation, and diarrhea. Things to remember when you fill your prescription. Unlike some other nausea medicines, the side effects for Zofran (ondansetron… Zofran Complaints Reported in Canada. Common Zofran side effects include: Side Effects. Side Effects What are the side effects of Ondansetron (Zofran)?. [Ref], Very common (10% or more): Eye disorder (up to 19%), Common (1% to 10%): Visual disturbance/transient visual disturbances (e.g., blurred vision), Very rare (less than 0.01%): Transient blindness, Frequency not reported: Swollen periocular area[Ref], Cardiopulmonary arrest and shock occurred during allergic reactions in patients given the IV formulation. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Decreased Oxygen In The Tissues Or Blood 7. It is available in brand and generic form. Abnormally Low Blood Pressure 4. Toxic Epidermal Necrolysis 17. Zofran side effects Get emergency medical help if you have any of these signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. There are no adequate studies of Zofran in pregnant women to determine its safe and effective use during pregnancy. 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